Understanding WT1 in Lung Scarring
WT1 REGULATION OF PULMONARY FIBROSIS
['FUNDING_R01'] · UNIVERSITY OF CINCINNATI · NIH-11134407
This research explores how a protein called WT1 contributes to the severe lung scarring seen in idiopathic pulmonary fibrosis, hoping to find new ways to stop the disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CINCINNATI (nih funded) |
| Locations | 1 site (CINCINNATI, UNITED STATES) |
| Trial ID | NIH-11134407 on ClinicalTrials.gov |
What this research studies
Idiopathic pulmonary fibrosis (IPF) is a serious lung disease where scar tissue builds up, making it hard to breathe. We know that certain cells called myofibroblasts are key to this scarring, but we don't fully understand what controls them. Our team has found that a protein called WT1 is increased in the lung cells of people with IPF and seems to play a harmful role. We are working to identify specific genes that WT1 influences, which could lead to new medications. The goal is to prevent these cells from causing more scarring and improve outcomes for patients.
Who could benefit from this research
Good fit: This foundational research focuses on understanding disease mechanisms and is not currently recruiting patients for direct participation.
Not a fit: Patients seeking immediate treatment options would not directly benefit from this early-stage laboratory research.
Why it matters
Potential benefit: If successful, this work could lead to new medications that target WT1 to prevent or slow down the progression of idiopathic pulmonary fibrosis.
How similar studies have performed: Our lab has recently published findings showing WT1's role in pulmonary fibrosis, and this work builds upon that initial success to identify specific therapeutic targets.
Where this research is happening
CINCINNATI, UNITED STATES
- UNIVERSITY OF CINCINNATI — CINCINNATI, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MADALA, SATISH K — UNIVERSITY OF CINCINNATI
- Study coordinator: MADALA, SATISH K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.