Understanding WNK Kinases and Kidney Health
Regulation of WNK signaling by potassium and Mo25: structure, function and physiology
This research helps us understand how certain proteins called WNKs work in the body, especially in the kidneys, to better address conditions like high blood pressure and kidney disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Utah State Higher Education System--University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-11139631 on NIH RePORTER |
What this research studies
Our bodies have special proteins called WNK kinases that help control how our kidneys manage salt and water. When these WNK proteins don't work correctly, it can lead to serious health issues like high blood pressure and chronic kidney disease. This project aims to uncover how these WNK proteins are normally controlled by factors like potassium and another protein called Mo25. By learning more about these control mechanisms, we hope to find new ways to help people whose WNK proteins are not functioning as they should.
Who could benefit from this research
Good fit: This foundational research is relevant to patients with conditions such as hyperkalemia, hypertension, and chronic kidney disease, particularly those linked to WNK kinase function.
Not a fit: Patients whose conditions are not related to WNK kinase function or kidney ion transport may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments or better management strategies for conditions like hyperkalemia, hypertension, and chronic kidney disease.
How similar studies have performed: This is a renewal application building on significant advances and preliminary data from a previously funded grant, indicating prior success and a strong foundation.
Where this research is happening
Salt Lake City, United States
- Utah State Higher Education System--University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Rodan, Aylin Rachel — Utah State Higher Education System--University of Utah
- Study coordinator: Rodan, Aylin Rachel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.