Understanding withdrawal symptoms from e-cigarettes and how nicotine affects them
Official title: Evaluation of the Electronic Cigarette Withdrawal Syndrome: Mechanistic Targets for Intervention
Funded at Johns Hopkins University · NIH-10930923 · Data updated 2026-11-12
This study is looking at how people who use e-cigarettes feel when they try to quit, focusing on the role of nicotine in causing withdrawal symptoms like cravings and mood changes, and it's for healthy adults who only use e-cigarettes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | September 30, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $719,506 |
| NIH project number | 5R01DA057925-02 |
| Project ID | NIH-10930923 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are healthy adults aged 21 and older who exclusively use e-cigarettes and are seeking to quit.
✕Less likely to help
Patients who do not use e-cigarettes or are under 21 years old may not benefit from this research.
What this research studies
This research investigates the withdrawal symptoms experienced by individuals who use e-cigarettes and are trying to quit. It aims to identify the specific role of nicotine in these withdrawal symptoms, which can include negative emotions, cravings, cognitive impairments, and sleep disturbances. Participants will be healthy adults who exclusively use e-cigarettes and will undergo a week of monitored abstinence in a residential setting. The study will utilize a controlled environment to gather data on how withdrawal manifests and the factors that may hinder cessation efforts.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for helping individuals quit e-cigarettes by understanding and addressing withdrawal symptoms.
How similar studies have gone: While there is limited controlled research on e-cigarette withdrawal, studies on traditional cigarette withdrawal have shown significant insights, suggesting potential for success in this novel approach.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Strickland, Justin Charles — Johns Hopkins University
- Study coordinator: Strickland, Justin Charles
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.