Understanding why weight loss stops in people
Physiological changes underlying the weight loss plateau in humans
This study is looking into why people often hit a weight loss plateau after shedding some pounds, focusing on how our body's metabolism and appetite play a role, so we can find better ways to help you keep the weight off for good.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10893498 on NIH RePORTER |
What this research studies
This research investigates the reasons behind the weight loss plateau that many individuals experience after losing a certain amount of weight. It focuses on how metabolic, appetitive, and neurological factors contribute to this phenomenon, which often leads to weight regain. The study will analyze changes in cellular energy metabolism in various tissues, including blood cells, muscle, and fat, to identify specific biological responses that occur during this plateau phase. By understanding these mechanisms, the research aims to develop more effective strategies for sustained weight loss.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who have experienced a weight loss plateau after losing 7-10% of their body weight.
Not a fit: Patients who have not attempted weight loss or those who are not experiencing a weight loss plateau may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved weight loss strategies that help individuals maintain their weight loss over the long term.
How similar studies have performed: Previous research has shown that understanding metabolic and neurological responses to weight loss can lead to better treatment approaches, indicating that this area of study has potential for significant advancements.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Schur, Ellen a — University of Washington
- Study coordinator: Schur, Ellen a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.