Understanding why tuberculosis affects more men than women
Genetic and hormonal mechanisms mediating sex differences in TB and TB-HIV
This study is looking into why more men than women get tuberculosis (TB) and is exploring how genes and hormones might play a role, with the hope of finding better ways to prevent and treat the disease for everyone.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10763804 on NIH RePORTER |
What this research studies
This research investigates the biological reasons behind the higher incidence of tuberculosis (TB) in males compared to females. It explores how genetic factors, particularly related to the X chromosome, and hormonal influences contribute to this disparity. By utilizing advanced animal models and human samples, the study aims to uncover the mechanisms that lead to differences in immune responses to TB between sexes. The findings could provide insights into better prevention and treatment strategies for TB.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a history of tuberculosis or those at high risk for TB, particularly males.
Not a fit: Patients who do not have tuberculosis or are not at risk for the disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment of tuberculosis, particularly for vulnerable populations.
How similar studies have performed: Previous studies have shown that understanding biological differences can lead to significant advancements in treatment approaches, indicating potential success for this research.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Bishai, William Ramses — Johns Hopkins University
- Study coordinator: Bishai, William Ramses
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.