Understanding why some women have difficulty getting pregnant due to hormonal issues.
Molecular mechanisms of endometrial progesterone resistance
This study is looking at why some women have trouble getting pregnant or staying pregnant due to their body's response to progesterone, focusing on a protein called MIG-6, to help find new ways to support those facing these challenges.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Missouri-Columbia NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project ID | NIH-10828347 on NIH RePORTER |
What this research studies
This research investigates the molecular mechanisms behind progesterone resistance in the endometrium, which can lead to infertility and miscarriage. By studying how the endometrial tissue responds to progesterone, the research aims to identify the underlying causes of implantation defects. The team will focus on a specific protein, MIG-6, to understand its role in progesterone signaling and how its dysfunction may contribute to reproductive challenges. This work could lead to new treatments for women facing difficulties in achieving or maintaining pregnancy.
Who could benefit from this research
Good fit: Ideal candidates for this research are women aged 15-44 who have experienced infertility or recurrent miscarriages.
Not a fit: Patients who are not experiencing infertility or miscarriage may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide new insights and potential treatments for women experiencing infertility and recurrent miscarriages.
How similar studies have performed: Previous research has shown promising results in understanding hormonal signaling in reproductive health, suggesting that this approach could yield valuable insights.
Where this research is happening
Columbia, United States
- University of Missouri-Columbia — Columbia, United States (Active)
Researchers
- Principal investigator: Jeong, Jae-Wook — University of Missouri-Columbia
- Study coordinator: Jeong, Jae-Wook
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.