Understanding why some vaccinated individuals still get Covid-19
VAccine failure: natural history and determinants of post-vaccination Covid-19
This study is looking at why some veterans aged 65 and older still get sick with Covid-19 even after being vaccinated, and it aims to learn more about how well the vaccine works over time.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Affairs Med Ctr San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11044121 on NIH RePORTER |
What this research studies
This research investigates the phenomenon of vaccine failure in individuals who have received Covid-19 vaccinations but still develop symptomatic disease. It aims to identify the clinical outcomes and factors that contribute to these cases, particularly focusing on veterans aged 65 and older. By utilizing real-time data from the Veterans Health Administration, the study will create a national cohort to monitor and analyze the epidemiology of post-vaccination Covid-19. The goal is to enhance understanding of how vaccine effectiveness may change over time and under different conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are veterans aged 65 and older who have received at least one dose of a Covid-19 vaccine and had a primary care visit in the past two years.
Not a fit: Patients who are younger than 65 years or those who have not received any Covid-19 vaccinations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved vaccination strategies and better protection for older adults against Covid-19.
How similar studies have performed: While there have been studies on vaccine efficacy, this specific focus on vaccine failure in older adults is relatively novel and aims to fill a critical gap in understanding.
Where this research is happening
San Francisco, United States
- Veterans Affairs Med Ctr San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Kelly, John Daniel — Veterans Affairs Med Ctr San Francisco
- Study coordinator: Kelly, John Daniel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.