Understanding why some Staphylococcus aureus infections don't respond to antibiotics
Microbial Genomic Determinants of Antibiotic Treatment Failure in Staphylococcus aureus Bacteremia
['FUNDING_CAREER'] · DUKE UNIVERSITY · NIH-11032978
This study is looking into why some people with a serious bloodstream infection caused by Staphylococcus aureus don't get better, by examining the bacteria and patient information to find out how the bacteria might be changing and resisting treatment, with the hope of finding better ways to help those affected.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DUKE UNIVERSITY (nih funded) |
| Locations | 1 site (DURHAM, UNITED STATES) |
| Trial ID | NIH-11032978 on ClinicalTrials.gov |
What this research studies
This research investigates the reasons behind treatment failures in patients with Staphylococcus aureus bacteremia, a serious bloodstream infection. By analyzing patient data and bacterial samples, the study aims to identify specific genetic changes in the bacteria that may contribute to their resistance against antibiotics. The researchers will use innovative laboratory models to simulate how these bacteria evolve and interact with the immune system. Ultimately, the goal is to improve treatment strategies for patients suffering from this infection.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with Staphylococcus aureus bacteremia who are undergoing antibiotic treatment.
Not a fit: Patients with other types of infections or those not infected with Staphylococcus aureus may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with Staphylococcus aureus bacteremia, reducing the risk of treatment failure.
How similar studies have performed: Previous research has shown that understanding microbial genetics can lead to significant advancements in treatment strategies for bacterial infections.
Where this research is happening
DURHAM, UNITED STATES
- DUKE UNIVERSITY — DURHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PARSONS, JOSHUA B — DUKE UNIVERSITY
- Study coordinator: PARSONS, JOSHUA B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: bacterial bloodstream infection