Understanding why some Staphylococcus aureus infections don't respond to antibiotics
Official title: Microbial Genomic Determinants of Antibiotic Treatment Failure in Staphylococcus aureus Bacteremia
Funded at Duke University · NIH-11032978 · Data updated 2026-11-12
This study is looking into why some people with a serious bloodstream infection caused by Staphylococcus aureus don't get better, by examining the bacteria and patient information to find out how the bacteria might be changing and resisting treatment, with the hope of finding better ways to help those affected.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | December 1, 2024 |
| Project end | November 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $189,558 |
| NIH project number | 1K08AI187747-01 |
| Project ID | NIH-11032978 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with Staphylococcus aureus bacteremia who are undergoing antibiotic treatment.
✕Less likely to help
Patients with other types of infections or those not infected with Staphylococcus aureus may not benefit from this research.
What this research studies
This research investigates the reasons behind treatment failures in patients with Staphylococcus aureus bacteremia, a serious bloodstream infection. By analyzing patient data and bacterial samples, the study aims to identify specific genetic changes in the bacteria that may contribute to their resistance against antibiotics. The researchers will use innovative laboratory models to simulate how these bacteria evolve and interact with the immune system. Ultimately, the goal is to improve treatment strategies for patients suffering from this infection.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with Staphylococcus aureus bacteremia, reducing the risk of treatment failure.
How similar studies have gone: Previous research has shown that understanding microbial genetics can lead to significant advancements in treatment strategies for bacterial infections.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Parsons, Joshua B — Duke University
- Study coordinator: Parsons, Joshua B
Related research
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-
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.