Understanding why some people with type 1 diabetes don't recognize low blood sugar
Official title: Elucidating the heterogeneity of impaired awareness of hypoglycaemia in type 1 diabetes
Funded at University of Leicester · NIH-11084309 · Data updated 2026-11-12
This study is looking into why some people with type 1 diabetes don’t notice when their blood sugar is low and aims to create new ways to measure this awareness, especially for those using advanced insulin delivery systems, to help improve education and management for better health.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Leicester NIH-funded |
| Lab location | 1 site (Leicester, United Kingdom) |
| Project start | September 25, 2022 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $376,313 |
| NIH project number | 5U01DK135128-03 |
| Project ID | NIH-11084309 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with type 1 diabetes who experience impaired awareness of hypoglycemia.
✕Less likely to help
Patients who do not have type 1 diabetes or those who do not experience issues with hypoglycemia awareness may not benefit from this research.
What this research studies
This research investigates the reasons behind impaired awareness of hypoglycemia (IAH) in individuals with type 1 diabetes. It aims to develop and validate new tools to objectively measure changes in awareness of low blood sugar levels, particularly in those using hybrid closed loop insulin delivery systems. The study will involve multiple sub-studies that assess physiological responses to low blood sugar and the effectiveness of advanced technology in restoring awareness. By understanding these factors, the research seeks to improve patient education and management strategies.
Why it matters
Potential benefit: If successful, this research could lead to better management of low blood sugar awareness in patients with type 1 diabetes, reducing the risk of severe hypoglycemic events.
How similar studies have gone: Previous research has shown promise in using technology to improve awareness of hypoglycemia, but this approach aims to refine and validate new assessment tools, making it a novel endeavor.
Where this research is happening
-
University of Leicester
Leicester, United Kingdom Active
Researchers
- Principal investigator: Choudhary, Pratik — University of Leicester
- Study coordinator: Choudhary, Pratik
Related research
Other NIH-funded projects on the same topics.
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Technological and Educational Approaches to Restore Hypoglycemia Awareness in Type 1 Diabetes
A two-arm study in adults with type 1 diabetes tests whether high-tech glucose control plus education or targeted training can help people regain awareness of low blood sugar.
-
Techniques for restoring awareness of low blood sugar in adults with type 1 diabetes
A randomized trial compares different approaches to help adults with type 1 diabetes recognize when their blood sugar is dipping so they can act quickly.
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Treating impaired hypoglycemia awareness in type 1 diabetes with targeted education and technology
This study tests two treatment approaches to help adults with type 1 diabetes who often don’t realize their blood sugar is getting too low, using a mix of technology and education in two large groups.
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Helping people with type 1 diabetes regain awareness of dangerous lows
A UK study tests two different approaches to help adults with type 1 diabetes recognize and respond to low blood sugar by comparing a high-tech insulin system with targeted education.
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How the pancreas environment affects insulin-producing cells in type 1 diabetes
Researchers are studying how the surrounding tissue of the pancreas and its proteins influence insulin-producing cells in people with type 1 diabetes.
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Understanding how hypoglycemia awareness changes in adults with type 1 diabetes and how automated insulin delivery and exercise might help restore it
This study will look at adults with type 1 diabetes to see how their awareness of low blood sugar evolves over time and whether automated insulin delivery and high-intensity exercise can help restore that awareness.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.