Understanding why some people resist tuberculosis infection despite high exposure
Characterization of Genomics and Metabolomics among Individuals Highly-Exposed, but resistant to Mtb Infection
This study is looking at why some people can stay healthy even after being around someone with tuberculosis (TB), and it’s for anyone who has been in close contact with a TB patient; researchers will compare those who don’t get sick with those who do to find out what helps protect them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-10433919 on NIH RePORTER |
What this research studies
This research investigates the genetic and metabolic factors that enable certain individuals to resist tuberculosis (TB) infection even after being exposed to the bacteria. By enrolling 4,000 household contacts of active TB patients, the study aims to compare those who remain uninfected with those who become infected. Advanced technologies will be used to analyze genetic and metabolic profiles, helping to identify protective mechanisms against TB. The findings could lead to new strategies for TB prevention and treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have been in close contact with active TB patients but have not contracted the infection themselves.
Not a fit: Patients who have already been diagnosed with active tuberculosis or those who have not been exposed to the disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new vaccines or therapies that enhance resistance to tuberculosis.
How similar studies have performed: Previous research has shown promise in identifying genetic factors related to TB resistance, but this study aims to expand on those findings with a larger cohort and advanced methodologies.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Gandhi, Neel Rajnikant — Emory University
- Study coordinator: Gandhi, Neel Rajnikant
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.