Understanding why some people don't respond well to Hepatitis B vaccination
Official title: A systems immunology approach for predicting poor responses to Hepatitis B vaccination
Funded at New York University School of Medicine · NIH-10897826 · Data updated 2026-11-12
This study is looking into why some people, especially those with conditions like obesity, don’t respond well to the Hepatitis B vaccine, and it aims to understand how certain immune cells affect this response by analyzing blood samples over time.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 17, 2021 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $806,881 |
| NIH project number | 5R01AI158617-04 |
| Project ID | NIH-10897826 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults over 21 years old, particularly those with chronic inflammatory conditions such as obesity.
✕Less likely to help
Patients who have already achieved a strong antibody response to the Hepatitis B vaccine may not benefit from this research.
What this research studies
This research investigates the reasons behind poor antibody responses to the Hepatitis B vaccine, particularly in individuals with chronic inflammatory conditions like obesity. By examining the role of specific immune cells, such as T follicular helper cells and B cells, the study aims to identify factors that influence the effectiveness of the vaccine. The researchers will analyze blood samples from participants to understand how these immune responses develop and change over time, providing insights that could lead to improved vaccination strategies.
Why it matters
Potential benefit: If successful, this research could lead to better vaccination strategies that ensure more individuals achieve protective immunity against Hepatitis B.
How similar studies have gone: Previous research has shown success in understanding immune responses to vaccines, but this specific approach to Hepatitis B vaccination is relatively novel.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Herati, Ramin — New York University School of Medicine
- Study coordinator: Herati, Ramin
Related research
Other NIH-funded projects on the same topics.
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This project looks for blood immune markers that explain why some adults, especially those with obesity, make weak antibody responses after hepatitis B vaccination.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.