Understanding why some people continue to misuse opioids despite negative consequences
Official title: Ventral pallidal transcriptional adaptations underlying punishment-resistant opioid intake
Funded at Washington University · NIH-11109604 · Data updated 2026-11-12
This study is looking at why some people with opioid use disorder keep using opioids even when it causes them problems, by exploring how a specific part of the brain works, and it aims to help improve treatment options for those affected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | September 30, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $808,655 |
| NIH project number | 5R01DA056829-03 |
| Project ID | NIH-11109604 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have a history of opioid use disorder and exhibit punishment-resistant drug-seeking behavior.
✕Less likely to help
Patients who do not have opioid use disorder or those who are not resistant to punishment in their drug-seeking behavior may not benefit from this research.
What this research studies
This research investigates the reasons behind why certain individuals with opioid use disorder (OUD) continue to seek and use opioids even when faced with negative outcomes, such as punishment. By studying the brain region known as the ventral pallidum, the researchers aim to uncover the neural mechanisms that contribute to this behavior. The study utilizes animal models to simulate human responses to opioid use and punishment, providing insights into the biological factors that influence drug-seeking behavior. The findings could lead to better understanding and treatment options for those struggling with OUD.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for opioid use disorder, helping patients reduce their drug-seeking behavior and improve their recovery outcomes.
How similar studies have gone: Previous research has shown success in understanding the neural mechanisms of drug-seeking behavior, making this approach promising for further advancements.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Creed, Meaghan C — Washington University
- Study coordinator: Creed, Meaghan C
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.