Understanding why some patients struggle to recover muscle function after serious illness
Cellular and Physical Function Outcomes Leading to Failed Muscle Recovery After Critical Illness
This study is looking into why some people have a hard time rebuilding their muscle strength and size after serious illnesses like sepsis or respiratory failure, and it aims to find ways to help them recover better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kentucky NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project ID | NIH-10887478 on NIH RePORTER |
What this research studies
This research investigates the reasons behind the difficulties some patients face in regaining muscle size and function after critical illnesses like sepsis and acute respiratory failure. By examining the cellular environment and processes involved in muscle recovery, the study aims to identify factors that hinder protein synthesis and muscle regrowth. Patients who have survived critical illness will be monitored to understand how their muscle and physical function evolve over time, which could lead to new therapies to enhance recovery.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who have survived critical illnesses such as sepsis or acute respiratory failure.
Not a fit: Patients who have not experienced critical illness or those with pre-existing chronic disabilities may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that help patients recover muscle function more effectively after critical illnesses.
How similar studies have performed: Other research has shown promising results in understanding muscle recovery mechanisms after critical illness, suggesting that this approach could yield valuable insights.
Where this research is happening
Lexington, United States
- University of Kentucky — Lexington, United States (Active)
Researchers
- Principal investigator: Mayer, Kirby P — University of Kentucky
- Study coordinator: Mayer, Kirby P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.