Understanding why some patients need more pain relief after tooth extraction
Mechanisms of Variability in the Analgesic Response to Ibuprofen Following Third Molar Extraction
This study is looking at why ibuprofen works differently for people after getting their wisdom teeth removed, and it aims to find out which patients might need extra pain relief, so they can get the best care without relying too much on opioids.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11139427 on NIH RePORTER |
What this research studies
This research investigates the reasons behind the varying effectiveness of ibuprofen for pain relief after third molar extractions. By examining individual patient factors, the study aims to identify which patients may require additional opioid medications alongside non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen. The approach includes analyzing biomarkers and other host factors to personalize pain management strategies, ultimately aiming to reduce unnecessary opioid prescriptions. Patients participating in this research may contribute to developing more effective pain management protocols that prioritize non-addictive medications.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals scheduled for third molar extractions who may experience varying levels of pain relief from ibuprofen.
Not a fit: Patients who are not undergoing third molar extractions or those who do not require pain management with NSAIDs may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more personalized pain management strategies that minimize opioid use and enhance recovery after dental procedures.
How similar studies have performed: Previous research has shown promising results in using precision medicine approaches to tailor pain management, indicating potential success for this study.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Theken, Katherine Nicole — University of Pennsylvania
- Study coordinator: Theken, Katherine Nicole
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.