Understanding why some patients need more pain relief after tooth extraction
Official title: Mechanisms of Variability in the Analgesic Response to Ibuprofen Following Third Molar Extraction
Funded at University of Pennsylvania · NIH-11139427 · Data updated 2026-11-12
This study is looking at why ibuprofen works differently for people after getting their wisdom teeth removed, and it aims to find out which patients might need extra pain relief, so they can get the best care without relying too much on opioids.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | July 16, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $690,510 |
| NIH project number | 5R01DE033405-02 |
| Project ID | NIH-11139427 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals scheduled for third molar extractions who may experience varying levels of pain relief from ibuprofen.
✕Less likely to help
Patients who are not undergoing third molar extractions or those who do not require pain management with NSAIDs may not benefit from this research.
What this research studies
This research investigates the reasons behind the varying effectiveness of ibuprofen for pain relief after third molar extractions. By examining individual patient factors, the study aims to identify which patients may require additional opioid medications alongside non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen. The approach includes analyzing biomarkers and other host factors to personalize pain management strategies, ultimately aiming to reduce unnecessary opioid prescriptions. Patients participating in this research may contribute to developing more effective pain management protocols that prioritize non-addictive medications.
Why it matters
Potential benefit: If successful, this research could lead to more personalized pain management strategies that minimize opioid use and enhance recovery after dental procedures.
How similar studies have gone: Previous research has shown promising results in using precision medicine approaches to tailor pain management, indicating potential success for this study.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Theken, Katherine Nicole — University of Pennsylvania
- Study coordinator: Theken, Katherine Nicole
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.