Understanding why some HIV patients struggle to recover immune function despite treatment
Investigate the mechanism of autoreactive B cell-mediated immunological failure despite virologic suppression in HIV-infected individuals on antiretroviral therapy
['FUNDING_OTHER'] · RALPH H JOHNSON VA MEDICAL CENTER · NIH-11051131
This study is looking into why some people with HIV don't get their immune cells back to healthy levels even when their virus is under control, and it hopes to find new ways to help them recover better by understanding certain antibodies in their bodies.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | RALPH H JOHNSON VA MEDICAL CENTER (nih funded) |
| Locations | 1 site (CHARLESTON, UNITED STATES) |
| Trial ID | NIH-11051131 on ClinicalTrials.gov |
What this research studies
This research investigates why some individuals living with HIV do not regain healthy levels of CD4+ T cells even when their viral load is suppressed by antiretroviral therapy. The study focuses on the role of specific antibodies that may contribute to the death of these immune cells. By examining the characteristics of autoreactive B cells and their antibodies, the research aims to identify potential therapeutic targets that could enhance immune recovery in these patients. The findings could lead to improved treatment strategies for those who do not respond well to current therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are HIV-infected individuals who are on antiretroviral therapy but have not achieved adequate recovery of their CD4+ T cell counts.
Not a fit: Patients who are not on antiretroviral therapy or those who have fully restored their CD4+ T cell counts may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that help restore immune function in HIV patients who currently do not respond to existing therapies.
How similar studies have performed: Previous research has indicated that targeting specific immune mechanisms can improve outcomes for HIV patients, suggesting that this approach may hold promise.
Where this research is happening
CHARLESTON, UNITED STATES
- RALPH H JOHNSON VA MEDICAL CENTER — CHARLESTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JIANG, WEI — RALPH H JOHNSON VA MEDICAL CENTER
- Study coordinator: JIANG, WEI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus