Understanding why some heart failure patients struggle with exercise
Mechanisms of Exercise Intolerance in Heart Failure With Preserved Ejection Fraction: Precision Therapy Based on Patient Specific Pathophysiology
This study is looking into why some people with heart failure and preserved heart function struggle to exercise, and it aims to find out more about their individual needs so that doctors can create better, personalized treatment plans just for them.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-10551294 on NIH RePORTER |
What this research studies
This research investigates the reasons behind exercise intolerance in patients with heart failure who have preserved ejection fraction (HFpEF). It aims to identify specific patient characteristics and mechanisms that contribute to their symptoms, particularly during physical activity. By linking multiple projects and cores, the research seeks to develop personalized therapies tailored to individual patient needs, moving away from standard treatments that may not be effective for everyone. Patients will be assessed to better understand their unique pathophysiology, which could lead to more effective management strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with heart failure with preserved ejection fraction who experience exercise intolerance and dyspnea.
Not a fit: Patients with heart failure who do not have preserved ejection fraction or those without significant exercise intolerance may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to personalized treatments that significantly improve the quality of life and physical functioning for patients with HFpEF.
How similar studies have performed: Previous research has indicated that personalized approaches to treating heart failure can lead to improved outcomes, suggesting that this research could build on established successes.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Levine, Benjamin D — Ut Southwestern Medical Center
- Study coordinator: Levine, Benjamin D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.