Understanding why some heart failure patients don't respond to diuretics
Mechanisms of diuretic resistance in heart failure
This study is looking into why some heart failure patients don't respond well to diuretics, which are medications that help remove extra fluid, and aims to find better ways to make these medications work more effectively for you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11103302 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind diuretic resistance in patients with heart failure, focusing on how the kidneys process these medications. It aims to identify specific transport pathways in the kidneys that contribute to this resistance, which can lead to persistent fluid buildup and worsening symptoms. By exploring the roles of various sodium transporters, the study seeks to find new ways to enhance diuretic effectiveness, potentially using existing FDA-approved medications. This could lead to improved management of heart failure symptoms and reduced hospitalizations for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults with heart failure who experience difficulty managing fluid retention despite diuretic therapy.
Not a fit: Patients with heart failure who do not experience diuretic resistance may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better treatment options for heart failure patients who struggle with diuretic resistance.
How similar studies have performed: Previous research has shown promise in targeting renal transport mechanisms to improve diuretic response, suggesting that this approach could be effective.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Testani, Jeffrey M — Yale University
- Study coordinator: Testani, Jeffrey M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.