Understanding why some genetic conditions cause constant hunger
Neural Mechanism of Impaired Satiation After Magel2 Mutation
['FUNDING_R21'] · UNIVERSITY OF ARIZONA · NIH-11160764
This research explores how changes in a specific gene might disrupt brain signals that tell us when we've had enough to eat, focusing on conditions like Prader-Willi Syndrome.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ARIZONA (nih funded) |
| Locations | 1 site (TUCSON, UNITED STATES) |
| Trial ID | NIH-11160764 on ClinicalTrials.gov |
What this research studies
Many people with genetic conditions like Prader-Willi Syndrome and Shafer-Young Syndrome experience constant hunger, even when their bodies produce signals that should make them feel full. We believe that a change in the Magel2 gene might prevent the brain from properly receiving and acting on these 'satiation' signals. Our team is looking closely at specific brain cells in an area called the amygdala to understand how they are affected when the Magel2 gene is altered. By understanding this process, we hope to uncover why these individuals feel insatiably hungry.
Who could benefit from this research
Good fit: This foundational research is for patients and families affected by genetic conditions like Prader-Willi Syndrome and Shafer-Young Syndrome, as it aims to understand the root causes of their symptoms.
Not a fit: Patients whose insatiable appetite is not linked to the Magel2 gene or similar genetic mechanisms may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to help manage the severe, insatiable hunger experienced by individuals with certain genetic conditions.
How similar studies have performed: Previous studies have identified the specific brain cells involved in detecting fullness signals, and preliminary results from this team suggest a link between the Magel2 gene and these cells' function.
Where this research is happening
TUCSON, UNITED STATES
- UNIVERSITY OF ARIZONA — TUCSON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CAI, HAIJIANG — UNIVERSITY OF ARIZONA
- Study coordinator: CAI, HAIJIANG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.