Understanding why some endometrial hyperplasia patients don't respond to progesterone treatment
Official title: Unravelling mechanisms and novel therapeutic targets for progesterone-resistant endometrial hyperplasia
Funded at University of Missouri-Columbia · NIH-11093422 · Data updated 2026-11-12
This study is looking into why some women with complex atypical hyperplasia or endometrial cancer don’t respond well to progesterone treatment, and it aims to find helpful signs that can predict how well they might do with this therapy, all while focusing on ways to help them keep their fertility.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Missouri-Columbia NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project start | August 4, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $458,895 |
| NIH project number | 5R01HD112332-03 |
| Project ID | NIH-11093422 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are reproductive-aged women diagnosed with complex atypical hyperplasia or endometrial cancer who are seeking fertility-sparing treatment options.
✕Less likely to help
Patients who have already undergone a hysterectomy or are not of childbearing age may not benefit from this research.
What this research studies
This research investigates the mechanisms behind progesterone resistance in complex atypical hyperplasia (CAH) and endometrial cancer (EC), which are conditions that can affect women's reproductive health. The study aims to identify biomarkers that predict how well patients will respond to progesterone therapy, a common treatment option. By focusing on fertility-sparing approaches, the research seeks to develop effective treatments that allow women to maintain their fertility while addressing these serious conditions. The methodology includes analyzing biological markers and signaling pathways involved in progesterone resistance.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for women with endometrial hyperplasia and cancer, allowing them to retain their fertility.
How similar studies have gone: Previous research has shown promise in understanding hormonal resistance in similar conditions, but this specific approach to progesterone resistance is relatively novel.
Where this research is happening
-
University of Missouri-Columbia
Columbia, United States Active
Researchers
- Principal investigator: Kim, Tae Hoon — University of Missouri-Columbia
- Study coordinator: Kim, Tae Hoon
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.