Understanding why some cancers become resistant to treatment and spread
Official title: Causal determinants of drug resistance and metastasis in cancer with multimodal single cell data
Funded at Sloan-Kettering Inst Can Research · NIH-10773164 · Data updated 2026-11-12
This study is looking into why some cancers, like small cell lung cancer, ovarian cancer, and stomach cancer, become resistant to treatment and spread, using advanced techniques to find out how genetic changes and other factors play a role, with the hope of creating better treatments for patients.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | February 1, 2023 |
| Project end | January 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $115,926 |
| NIH project number | 5K99CA277562-02 |
| Project ID | NIH-10773164 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include patients diagnosed with small cell lung cancer, high-grade serous ovarian cancer, or gastric adenocarcinoma who are experiencing treatment resistance.
✕Less likely to help
Patients with cancers that are not included in this research focus may not receive any benefit from the findings.
What this research studies
This research investigates the reasons behind drug resistance and metastasis in certain types of cancer, specifically small cell lung cancer, high-grade serous ovarian cancer, and gastric adenocarcinoma. By utilizing advanced single-cell analysis techniques, the study aims to differentiate between genetic mutations and adaptive changes that contribute to treatment failure. The researchers will develop new statistical models to better understand these mechanisms, which could lead to more effective therapies for patients facing these aggressive cancers.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies that overcome drug resistance in cancer patients.
How similar studies have gone: Other research has shown promise in using single-cell analysis to understand cancer mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Sloan-Kettering Inst Can Research
New York, United States Active
Researchers
- Principal investigator: Salehi, Sohrab — Sloan-Kettering Inst Can Research
- Study coordinator: Salehi, Sohrab
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.