Understanding why some cancers become resistant to treatment and spread
Causal determinants of drug resistance and metastasis in cancer with multimodal single cell data
['FUNDING_CAREER'] · SLOAN-KETTERING INST CAN RESEARCH · NIH-10773164
This study is looking into why some cancers, like small cell lung cancer, ovarian cancer, and stomach cancer, become resistant to treatment and spread, using advanced techniques to find out how genetic changes and other factors play a role, with the hope of creating better treatments for patients.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SLOAN-KETTERING INST CAN RESEARCH (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10773164 on ClinicalTrials.gov |
What this research studies
This research investigates the reasons behind drug resistance and metastasis in certain types of cancer, specifically small cell lung cancer, high-grade serous ovarian cancer, and gastric adenocarcinoma. By utilizing advanced single-cell analysis techniques, the study aims to differentiate between genetic mutations and adaptive changes that contribute to treatment failure. The researchers will develop new statistical models to better understand these mechanisms, which could lead to more effective therapies for patients facing these aggressive cancers.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients diagnosed with small cell lung cancer, high-grade serous ovarian cancer, or gastric adenocarcinoma who are experiencing treatment resistance.
Not a fit: Patients with cancers that are not included in this research focus may not receive any benefit from the findings.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies that overcome drug resistance in cancer patients.
How similar studies have performed: Other research has shown promise in using single-cell analysis to understand cancer mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
NEW YORK, UNITED STATES
- SLOAN-KETTERING INST CAN RESEARCH — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SALEHI, SOHRAB — SLOAN-KETTERING INST CAN RESEARCH
- Study coordinator: SALEHI, SOHRAB
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, neoplasm/cancer