Understanding why some blood vessels are more prone to aneurysms
MECHANISTIC BASIS FOR REGIONAL PREDISPOSITION FOR ANEURYSM
This study is looking into why some parts of blood vessels are more likely to develop aneurysms, which can be serious, and it aims to find ways to prevent and treat them by understanding the genetic factors and signals involved.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10662256 on NIH RePORTER |
What this research studies
This research investigates the biological mechanisms that make certain regions of blood vessels more susceptible to aneurysms, which are dangerous dilations that can lead to severe health issues. By studying genetic conditions linked to aneurysms, the research aims to identify key signaling pathways and proteins involved in the development and maintenance of vascular cells. The goal is to uncover why aneurysms predominantly occur in specific areas of the aorta, which could lead to targeted therapies for prevention and treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with hereditary conditions like Loeys-Dietz Syndrome or autosomal recessive cutis laxa type 1B, which are associated with a higher risk of aneurysms.
Not a fit: Patients without genetic predispositions to aneurysms or those with other unrelated vascular conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that prevent aneurysms from developing or rupturing, significantly improving patient outcomes.
How similar studies have performed: Previous research on genetic conditions related to aneurysms has shown promising results, indicating that understanding the underlying mechanisms can lead to effective interventions.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Gallo Macfarlane, Elena — Johns Hopkins University
- Study coordinator: Gallo Macfarlane, Elena
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.