Understanding why people have different levels of gum inflammation
Official title: Mechanisms underlying the variation in rate and levels of gingival inflammatory responses among the human population
Funded at University of Washington · NIH-10996174 · Data updated 2026-11-12
This study is looking at why some people have different levels of gum inflammation and health, and it’s for anyone interested in understanding how their unique body might affect their gum health, so we can create better, personalized ways to keep their gums healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | January 1, 2023 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $499,446 |
| NIH project number | 5R01DE031470-03 |
| Project ID | NIH-10996174 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who are experiencing varying levels of gum inflammation or are at risk for periodontal disease.
✕Less likely to help
Patients with no gum inflammation or those who have already been diagnosed with advanced periodontal disease may not benefit from this research.
What this research studies
This research investigates the reasons behind the varying inflammatory responses in gum health among individuals. By utilizing advanced gene sequencing techniques, the study aims to identify how different factors contribute to periodontal health and disease. The findings will help develop personalized prevention and treatment strategies tailored to each person's unique immune response. Participants may undergo assessments that involve monitoring their gum health and the oral microbiome.
Why it matters
Potential benefit: If successful, this research could lead to personalized treatment plans that improve gum health and prevent periodontal disease.
How similar studies have gone: Previous research using similar experimental models has shown promise in understanding gum health and disease, indicating that this approach could yield valuable insights.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Mclean, Jeffrey Scott — University of Washington
- Study coordinator: Mclean, Jeffrey Scott
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.