Understanding why older adults are more prone to lung infections from non-tuberculous mycobacteria
Mechanisms of increased susceptibility to pulmonary Nontuberculous Mycobacterial disease in the elderly
This study is looking into why older adults are more likely to get lung diseases from certain germs, and it aims to understand how changes in their immune system and lung bacteria play a role, so we can find better ways to prevent and treat these infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kentucky NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project ID | NIH-10802365 on NIH RePORTER |
What this research studies
This research investigates the reasons behind the increased vulnerability of elderly individuals to lung diseases caused by non-tuberculous mycobacteria (NTM). The study aims to explore how age-related changes in immune response and lung microbiome contribute to this susceptibility. By using a rhesus macaque model, researchers will examine the immune mechanisms and environmental factors that may lead to chronic lung infections in older adults. The findings could provide insights into better prevention and treatment strategies for this growing health concern.
Who could benefit from this research
Good fit: Ideal candidates for this research are elderly individuals, particularly those aged 65 and older, who may be at risk for pulmonary NTM disease.
Not a fit: Patients who are younger than 65 or those without any history of lung disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of lung infections in older adults, potentially reducing the incidence and severity of these diseases.
How similar studies have performed: While there is ongoing research into lung infections in older adults, this specific approach using a translational animal model to study NTM susceptibility is relatively novel.
Where this research is happening
Lexington, United States
- University of Kentucky — Lexington, United States (Active)
Researchers
- Principal investigator: Messaoudi, Ilhem — University of Kentucky
- Study coordinator: Messaoudi, Ilhem
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.