Understanding why men and women experience different risks and outcomes for aortic aneurysms.
Mechanisms of sex-biased risk and resiliency in aneurysm and dissection
['FUNDING_R01'] · CEDARS-SINAI MEDICAL CENTER · NIH-10904012
This study is looking at why men and women experience aortic aneurysms differently, focusing on how hormones might play a role, and it aims to find ways to improve prevention and treatment for everyone.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CEDARS-SINAI MEDICAL CENTER (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-10904012 on ClinicalTrials.gov |
What this research studies
This research investigates the biological and social factors that contribute to the differences in how men and women are affected by aortic aneurysms and dissections. It aims to identify the molecular mechanisms that lead to these sex differences, particularly focusing on the role of female hormones like estrogen and progesterone. By using a mouse model and advanced proteomics techniques, the study seeks to uncover protective pathways in women that could inform better prevention and treatment strategies for both sexes. The findings could help clarify why women are diagnosed later and often have worse outcomes compared to men.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of aortic aneurysms or dissections, particularly women who may be at higher risk.
Not a fit: Patients who do not have a history of arterial disorders or those who are not affected by aortic aneurysms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment strategies for aortic aneurysms, particularly for women who are currently underserved.
How similar studies have performed: Previous research has shown that understanding sex differences in disease mechanisms can lead to significant advancements in treatment, suggesting that this approach has potential for success.
Where this research is happening
LOS ANGELES, UNITED STATES
- CEDARS-SINAI MEDICAL CENTER — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PARKER, SARAH J — CEDARS-SINAI MEDICAL CENTER
- Study coordinator: PARKER, SARAH J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Arterial Disorder, Candidate Disease Gene