Understanding why lung cancer resists certain treatments
Mechanism of lung cancer resistance to tyrosine kinase inhibitor and radiation treatments
This study is looking into why some lung cancer cells don't respond well to certain treatments, like targeted therapies and radiation, by exploring specific proteins and genes, with the hope of finding new ways to make these treatments work better for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Thomas Jefferson University NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10470829 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind lung cancer's resistance to tyrosine kinase inhibitors and radiation treatments. It focuses on the role of specific proteins and genetic factors that contribute to this resistance. By studying the activation of p70S6K1 and the expression of NOX4 and EZH2 in resistant lung cancer cells, the researchers aim to identify potential targets for improving treatment outcomes. Patients may benefit from insights that could lead to more effective therapies for lung cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are lung cancer patients who have shown resistance to tyrosine kinase inhibitors or radiation treatments.
Not a fit: Patients with early-stage lung cancer who have not yet undergone treatment may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for lung cancer patients who currently do not respond to existing therapies.
How similar studies have performed: Previous research has shown promising results in understanding treatment resistance in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
Philadelphia, United States
- Thomas Jefferson University — Philadelphia, United States (Active)
Researchers
- Principal investigator: Simone, Nicole L — Thomas Jefferson University
- Study coordinator: Simone, Nicole L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.