Understanding why HIV-infected women in South Africa have adverse birth outcomes
Official title: MECHANISMS LEADING TO ADVERSE BIRTH OUTCOMES IN SOUTH AFRICAN HIV-INFECTED WOMEN
Funded at Stellenbosch University · NIH-10811664 · Data updated 2026-11-12
This study is looking at how certain factors might affect pregnancy outcomes for women with HIV in South Africa, focusing on the health of both mothers and their babies, to help find ways to prevent complications during pregnancy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stellenbosch University NIH-funded |
| Lab location | 1 site (Stellenbosch, SOUTH AFRICA) |
| Project start | April 3, 2020 |
| Project end | March 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $325,093 |
| NIH project number | 5R01HD102050-05 |
| Project ID | NIH-10811664 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are pregnant women living with HIV in South Africa.
✕Less likely to help
Patients who are not HIV-infected or those who are not pregnant may not receive any benefit from this research.
What this research studies
This research investigates the factors leading to adverse birth outcomes, such as pre-term birth, in HIV-infected women in South Africa. By studying the vaginal microbiome and metabolic markers, the research aims to identify specific communities and pathways that may contribute to complications during pregnancy. The study will utilize advanced techniques like 16S rRNA sequencing to analyze samples from pregnant women in Cape Town, aiming to uncover the relationship between HIV, antiretroviral treatment, and infant health outcomes. The ultimate goal is to develop prevention strategies to improve maternal and neonatal health.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing adverse birth outcomes in HIV-infected women, enhancing both maternal and infant health.
How similar studies have gone: Previous research has shown that understanding the microbiome and metabolic factors can influence pregnancy outcomes, suggesting potential for success in this approach.
Where this research is happening
-
Stellenbosch University
Stellenbosch, South Africa Active
Researchers
- Principal investigator: Gray, Clive Maurice — Stellenbosch University
- Study coordinator: Gray, Clive Maurice
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.