Understanding why Group B Strep urinary infections are common in people with type 2 diabetes
Contribution of immune modulation, metabolism, and microbiota to Group B Streptococcal urinary tract infection
This project looks at how the immune system, body processes, and gut bacteria might make people with type 2 diabetes more likely to get severe urinary tract infections caused by Group B Streptococcus.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11161568 on NIH RePORTER |
What this research studies
Urinary tract infections (UTIs) are a common problem, especially for women, but they can be more serious for people with type 2 diabetes. This research aims to uncover why individuals with diabetes are more susceptible to UTIs, particularly those caused by Group B Streptococcus (GBS). We want to find out if changes in the body's defenses, how bacteria behave, or differences in vaginal bacteria contribute to this increased risk. By understanding these factors, we hope to find new ways to prevent and treat these infections.
Who could benefit from this research
Good fit: This research is focused on understanding the biology of urinary tract infections in people with type 2 diabetes.
Not a fit: Patients without type 2 diabetes or those with UTIs not caused by Group B Streptococcus may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to prevent and treat severe urinary tract infections in people with type 2 diabetes.
How similar studies have performed: Preliminary studies in animal models have shown connections between diabetes and increased susceptibility to GBS UTIs, suggesting this approach builds on existing knowledge.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Patras, Katy — Baylor College of Medicine
- Study coordinator: Patras, Katy
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.