Understanding why drug responses vary among people
Computational methods for characterizing sources of variability in drug response
This work uses advanced computer tools to understand why different people respond to medications in different ways, aiming for safer and more effective treatments for everyone.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-11194276 on NIH RePORTER |
What this research studies
We know that drugs work differently for each person, sometimes leading to side effects or not being as effective as hoped. This project uses powerful computer methods to look at vast amounts of information, including your genetic makeup, how your body's cells work, and real-world patient experiences from medical records. By bringing all this data together, we hope to uncover the detailed reasons behind these differences in drug response. Our goal is to help doctors choose the right medication and dose for you, making treatments more precise and personalized.
Who could benefit from this research
Good fit: This foundational computational work is relevant to all patients who take medications, as it aims to improve understanding of drug response across diverse populations.
Not a fit: Patients not currently taking medications or those whose conditions are not treated with drugs may not directly benefit from this specific research focus.
Why it matters
Potential benefit: If successful, this work could lead to more personalized drug therapies, reducing side effects and improving treatment effectiveness for many conditions.
How similar studies have performed: The research team has a strong track record in this area, including creating the Pharmacogenetics Knowledgebase (PharmGKB), which curates information on how human genetics affect drug response.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Altman, Russ Biagio — Stanford University
- Study coordinator: Altman, Russ Biagio
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.