Understanding why dialysis fistulas fail to mature
Translational and Computational Analysis of Dialysis Fistula Maturation Failure-2
['FUNDING_R01'] · UNIVERSITY OF FLORIDA · NIH-10479081
This study is looking at how different factors influence the growth and success of arteriovenous fistulas (AVFs) for people on dialysis, with the goal of finding better ways to help these fistulas mature properly and improve treatment outcomes.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF FLORIDA (nih funded) |
| Locations | 1 site (GAINESVILLE, UNITED STATES) |
| Trial ID | NIH-10479081 on ClinicalTrials.gov |
What this research studies
This research investigates the biological and mechanical factors that affect the maturation of arteriovenous fistulas (AVFs), which are crucial for patients undergoing dialysis. By examining how blood flow and cellular responses interact in the unique environment of AVFs, the study aims to identify the mechanisms that lead to successful or failed maturation. The research employs advanced genomic analysis and computational modeling to uncover critical changes in the cells involved. Ultimately, this work seeks to inform the development of new therapies that can enhance AVF outcomes for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients who require dialysis and are at risk of arteriovenous fistula maturation failure.
Not a fit: Patients who do not require dialysis or have alternative vascular access methods may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that enhance the success rates of dialysis fistulas, benefiting patients who rely on dialysis for kidney function.
How similar studies have performed: Previous research has shown promise in understanding vascular remodeling, suggesting that this approach could yield significant insights and advancements.
Where this research is happening
GAINESVILLE, UNITED STATES
- UNIVERSITY OF FLORIDA — GAINESVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BERCELI, SCOTT A — UNIVERSITY OF FLORIDA
- Study coordinator: BERCELI, SCOTT A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.