Understanding why diabetic corneas heal poorly after injury
Delayed wound healing in diabetic corneal epithelia: reduction in protein response after injury and uncoordinated cell-cell communication
This study is looking into why people with type 2 diabetes have trouble healing their eye wounds, which can affect their vision, and it hopes to find ways to help these wounds heal better.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10865139 on NIH RePORTER |
What this research studies
This research investigates the reasons behind delayed wound healing in the corneas of patients with type 2 diabetes, which can lead to significant vision loss. The study focuses on the cellular mechanisms involved in wound healing, particularly the role of specific proteins and cell communication pathways. By examining how these processes differ in diabetic patients compared to healthy individuals, the research aims to identify potential targets for improving healing responses. The findings could lead to better treatment options for patients suffering from non-healing corneal injuries.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with type 2 diabetes who experience non-healing corneal injuries.
Not a fit: Patients without diabetes or those with other types of corneal injuries unrelated to diabetes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for diabetic patients with corneal injuries, potentially reducing vision loss.
How similar studies have performed: Previous studies have shown promising results in understanding cellular signaling in wound healing, suggesting that this approach could yield valuable insights.
Where this research is happening
Boston, United States
- Boston University Medical Campus — Boston, United States (Active)
Researchers
- Principal investigator: Segars, Kristen — Boston University Medical Campus
- Study coordinator: Segars, Kristen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.