Understanding why certain human brain cells are vulnerable to aging
Human‐specific vulnerabilities and compensatory adaptations to age‐related stressors in selectively vulnerable midbrain dopaminergic neurons
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-11168872
This project aims to discover why specific brain cells in humans become vulnerable with age, contributing to conditions like Parkinson's disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-11168872 on ClinicalTrials.gov |
What this research studies
Our brains have evolved uniquely, and some brain cells, like those involved in movement and mood, might be under extra stress as we age. This project explores why these particular cells are more susceptible to age-related damage in humans compared to other primates. We are using advanced techniques, including human stem cell models and comparing human brain tissue with that of chimpanzees and macaques. By understanding these human-specific vulnerabilities and protective mechanisms, we hope to find new ways to keep these vital brain cells healthy.
Who could benefit from this research
Good fit: This research is relevant for individuals interested in the biological causes of age-related brain conditions, particularly those affecting dopamine-producing neurons, such as Parkinson's disease.
Not a fit: Patients whose conditions are not related to age-related vulnerabilities of midbrain dopaminergic neurons may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of age-related brain disorders like Parkinson's disease and help identify new strategies to protect vulnerable brain cells.
How similar studies have performed: This project explores a relatively new area by examining the evolution of selective vulnerability and compensatory mechanisms specifically in the human lineage.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: POLLEN, ALEXANDER A — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: POLLEN, ALEXANDER A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.