Understanding why breast cancer treatments cause exercise intolerance in veterans
Mechanisms of systemic dysfunction responsible for exercise intolerance induced by breast cancer, cytotoxic chemotherapy, and endocrine therapy in Veterans
['FUNDING_OTHER'] · VA SALT LAKE CITY HEALTHCARE SYSTEM · NIH-10937994
This study is looking at how breast cancer and its treatments can make it hard for veterans to exercise, and it aims to find out why this happens so that we can help improve their physical health and overall quality of life.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VA SALT LAKE CITY HEALTHCARE SYSTEM (nih funded) |
| Locations | 1 site (SALT LAKE CITY, UNITED STATES) |
| Trial ID | NIH-10937994 on ClinicalTrials.gov |
What this research studies
This research investigates how breast cancer and its treatments, particularly cytotoxic and endocrine therapies, lead to exercise intolerance in veterans. It aims to identify the underlying mechanisms of systemic dysfunction that affect physical function and quality of life. By examining the role of reactive oxygen and nitrogen species, as well as the impact on peripheral vascular, mitochondrial, and neuromuscular systems, the study seeks to uncover potential therapeutic targets. The goal is to improve the effectiveness of cancer therapies while preserving patients' quality of life.
Who could benefit from this research
Good fit: Ideal candidates for this research are women veterans diagnosed with stage I-III breast cancer who are undergoing cytotoxic or endocrine therapies.
Not a fit: Patients with breast cancer who are not receiving cytotoxic or endocrine therapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies that enhance exercise tolerance and overall quality of life for breast cancer patients.
How similar studies have performed: Previous research has shown that addressing systemic dysfunction can improve outcomes in cancer patients, suggesting that this approach may yield beneficial results.
Where this research is happening
SALT LAKE CITY, UNITED STATES
- VA SALT LAKE CITY HEALTHCARE SYSTEM — SALT LAKE CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BROXTERMAN, RYAN MICHAEL — VA SALT LAKE CITY HEALTHCARE SYSTEM
- Study coordinator: BROXTERMAN, RYAN MICHAEL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Breast Cancer, Breast Cancer therapy, Cancer Treatment, Cancers