Understanding why Black individuals with HCM have worse heart outcomes
Determining Potential Mechanisms of Worse Outcomes in Black HCM Patients
This research aims to understand why hypertrophic cardiomyopathy (HCM) affects Black individuals more severely, leading to worse heart health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11099716 on NIH RePORTER |
What this research studies
Hypertrophic cardiomyopathy (HCM) is a common inherited heart condition that can lead to serious problems like heart failure and sudden cardiac death. We know that HCM is often underdiagnosed in Black individuals, even though they may show more signs of the condition. Even after diagnosis, Black patients often receive less specialized care, genetic testing, and preventative treatments compared to White patients. This project seeks to uncover the specific reasons behind these differences, which could include unique disease characteristics or how the condition is managed.
Who could benefit from this research
Good fit: This research is relevant for Black adults, aged 21 and older, who have or are at risk for hypertrophic cardiomyopathy.
Not a fit: Patients who do not have hypertrophic cardiomyopathy or are not part of the Black population may not directly benefit from this specific research focus.
Why it matters
Potential benefit: If successful, this work could lead to better diagnosis, more equitable care, and improved outcomes for Black individuals living with HCM.
How similar studies have performed: While disparities in HCM outcomes are recognized, this research aims to uncover the underlying mechanisms, which is a novel and critical step toward addressing these known issues.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Cresci, Sharon — Washington University
- Study coordinator: Cresci, Sharon
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.