Understanding why Black and White patients experience different rates of heart disease and stroke.
Official title: REasons for Geographic And Racial Differences in Stroke-Myocardial Infarction-4 (REGARDS-MI-4)
Funded at Weill Medical Coll of Cornell Univ · NIH-10904966 · Data updated 2026-11-12
This study is looking at why Black and White people in the U.S. experience different rates of heart disease and heart failure, focusing on how social factors and racism play a role, and it aims to understand how people bounce back from heart health issues to help improve care for everyone.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 10, 2022 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $1,926,124 |
| NIH project number | 5R01HL165452-03 |
| Project ID | NIH-10904966 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include Black and White adults who are at risk for or have experienced coronary heart disease or heart failure.
✕Less likely to help
Patients who do not identify as Black or White or those without a history of cardiovascular issues may not benefit from this research.
What this research studies
This research investigates the persistent disparities in coronary heart disease (CHD) and heart failure (HF) between Black and White populations in the U.S. It focuses on how social determinants of health, including structural racism, impact these disparities over a person's lifetime. By examining resilience and recovery after acute health events, the study aims to uncover the underlying mechanisms contributing to these health differences. The research will utilize a national sample to provide rigorously adjudicated data on CHD and HF events, which can be used by other investigators as well.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and interventions that reduce heart disease and stroke disparities among different racial groups.
How similar studies have gone: Previous research has shown that addressing social determinants of health can lead to meaningful improvements in health outcomes, suggesting potential success for this approach.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Safford, Monika M — Weill Medical Coll of Cornell Univ
- Study coordinator: Safford, Monika M
Related research
Other NIH-funded projects on the same topics.
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Why heart attacks and strokes affect people differently across places and races
This project follows adults across the U.S. to see how lifelong social and neighborhood factors shape heart attacks, heart failure, and recovery, with attention to Black adults and regions with high disease rates.
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This project explores how lifelong social and neighborhood factors shape the risk of heart attacks and heart failure and how well adults recover, especially across different racial groups and U.S. regions.
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Understanding why Black and White patients experience different rates of heart disease and heart failure.
This study is looking at why Black and White people in the U.S. experience heart disease and heart failure differently, focusing on how social factors and racism play a role, and it aims to help researchers understand these issues better while also supporting new scientists from diverse backgrounds.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.