Understanding why autoimmune diseases affect women more than men.
Determinants of sex disparities in autoimmune endocrinopathies.
This study is looking into why autoimmune hormone-related conditions are more common in women than in men, focusing on how hormones and genetics might play a role, and it invites patients to help by providing samples to better understand these differences.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10845212 on NIH RePORTER |
What this research studies
This research investigates the reasons behind the higher prevalence of autoimmune endocrinopathies in women compared to men. It focuses on the roles of sex hormones, particularly androgens, and genetic factors such as X chromosome copy number in influencing immune responses. By examining how these factors affect the differentiation of immune cells, the study aims to uncover the biological mechanisms that contribute to these sex disparities. Patients may be involved in providing samples to help explore these differences further.
Who could benefit from this research
Good fit: Ideal candidates for participation include individuals diagnosed with autoimmune endocrinopathies, particularly women, as well as men with Klinefelter Syndrome.
Not a fit: Patients with autoimmune conditions that do not involve endocrine glands or those without a sex disparity may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for autoimmune diseases that disproportionately affect women.
How similar studies have performed: Previous research has indicated that hormonal and genetic factors play significant roles in autoimmune diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Su, Maureen a — University of California Los Angeles
- Study coordinator: Su, Maureen a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.