Understanding white matter damage in Alzheimer's disease
Mechanism of white matter pathology in Alzheimer's disease
['FUNDING_R01'] · CASE WESTERN RESERVE UNIVERSITY · NIH-10979146
This study is looking at how the loss of certain brain cells, called oligodendrocytes, affects myelin and may play a role in the early stages of Alzheimer's disease, with the hope of finding new ways to help improve brain health for those living with the condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CASE WESTERN RESERVE UNIVERSITY (nih funded) |
| Locations | 1 site (CLEVELAND, UNITED STATES) |
| Trial ID | NIH-10979146 on ClinicalTrials.gov |
What this research studies
This research investigates how the death of oligodendrocytes, which are crucial for maintaining myelin in the brain, contributes to the early stages of Alzheimer's disease. By examining changes in white matter, including myelin loss and inflammation, the study aims to uncover the mechanisms behind cognitive decline in patients. The researchers utilize advanced techniques such as proteomic analysis and single-cell transcriptomics to explore the role of oligodendrocytes in Alzheimer's pathology. This work could lead to new insights into potential therapeutic targets for improving brain health in affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults aged 21 and older who are experiencing cognitive decline associated with Alzheimer's disease.
Not a fit: Patients with other forms of dementia or neurodegenerative diseases unrelated to Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that protect or restore white matter integrity in Alzheimer's patients, potentially improving cognitive function.
How similar studies have performed: Previous studies have shown promising results in understanding the role of oligodendrocytes in neurodegeneration, suggesting that this research could build on established findings.
Where this research is happening
CLEVELAND, UNITED STATES
- CASE WESTERN RESERVE UNIVERSITY — CLEVELAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: QI, XIN — CASE WESTERN RESERVE UNIVERSITY
- Study coordinator: QI, XIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: age associated neurodegenerative disease, age associated neurodegenerative disorder, age dependent neurodegenerative disease