Understanding which genes and tissues change blood pressure
From GWAS loci to blood pressure genes, variants & mechanisms - Renewal
This project looks at how differences in genes and gene control in organs like arteries, heart, kidneys, and adrenal glands can cause high or low blood pressure for people with hypertension.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11358390 on NIH RePORTER |
What this research studies
Researchers will combine large-scale human DNA data with maps of gene regulation to see which tissues and cell types matter most for blood pressure. They will focus on arteries, heart, adrenal glands and kidneys to find the specific genes and regulatory switches that change systolic and diastolic pressure. The team will map transcription factors, regulatory elements, and gene networks to show how genetic variants lead to blood pressure differences between people. Results will be compared across many international datasets to build a clearer picture of tissue-specific causes.
Who could benefit from this research
Good fit: Adults with measured blood pressure, especially people with hypertension who can provide DNA or consent to use their genetic/epigenetic data, would be the most relevant candidates for related studies.
Not a fit: People without blood pressure concerns or those seeking an immediate new therapy are unlikely to get direct short-term benefits from this basic genetic mapping work.
Why it matters
Potential benefit: If successful, this work could point to precise genes and tissues to target for new blood pressure treatments and more personalized care.
How similar studies have performed: Large genome-wide studies have already found many blood pressure–linked variants, but combining genome and epigenome screens to map tissue-specific mechanisms is a newer and still developing approach.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Chakravarti, Aravinda — New York University School of Medicine
- Study coordinator: Chakravarti, Aravinda
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.