Understanding which fluid is best for patients with sepsis
Finding Appropriate Subtypes in a Trial of Balanced versus nOrmaL Saline FlUid in Sepsis
This research aims to discover if certain types of intravenous fluids work better for specific children and adults who have sepsis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11141009 on NIH RePORTER |
What this research studies
Sepsis is a serious condition where the body overreacts to an infection, affecting many children and adults each year. While antibiotics and fluids are key treatments, doctors are still debating which type of fluid is best. Previous work in adults suggests that 'balanced' fluids might be better for kidney health than 'normal saline.' This project will look closely at information from a large ongoing effort called PRoMPT BOLUS, which is comparing these fluids in children with sepsis, to find out if certain patient groups respond better to one fluid over another.
Who could benefit from this research
Good fit: This research is relevant to children and adults who have been diagnosed with sepsis and received fluid resuscitation.
Not a fit: Patients without sepsis or those not receiving intravenous fluid resuscitation would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could help doctors choose the most effective intravenous fluid for individual patients with sepsis, potentially improving kidney outcomes and survival.
How similar studies have performed: Previous large studies in adults have shown that balanced crystalloid solutions may lead to better kidney outcomes compared to normal saline in sepsis.
Where this research is happening
Philadelphia, United States
- Children's Hosp of Philadelphia — Philadelphia, United States (Active)
Researchers
- Principal investigator: Yehya, Nadir — Children's Hosp of Philadelphia
- Study coordinator: Yehya, Nadir
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.