Understanding when Parkinson's disease mutations start causing problems in mice
Determining the critical time window of action of Parkinson mutant alpha synuclein expression in mice
['FUNDING_R21'] · JOHNS HOPKINS UNIVERSITY · NIH-11017832
This study is looking at how changes in genes linked to Parkinson's disease affect the brain and body in mice at different ages, which could help us spot early signs of the disease and understand how it develops.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-11017832 on ClinicalTrials.gov |
What this research studies
This research investigates the timeline of how mutations associated with Parkinson's disease affect the brain and body in mice. By studying these mutations, the researchers aim to determine if there is a critical period during which these mutations lead to significant neurological changes. The approach involves using mouse models that express these mutations at different life stages to observe the resulting effects on behavior and brain function. This could help identify early signs of Parkinson's disease and improve understanding of its progression.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of Parkinson's disease or those experiencing early symptoms such as sleep disturbances or anosmia.
Not a fit: Patients with advanced Parkinson's disease or those who do not have any genetic predisposition to the disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection and intervention strategies for Parkinson's disease, potentially improving patient outcomes.
How similar studies have performed: Other research has shown that understanding the timing of genetic mutations can significantly impact disease progression, suggesting that this approach may yield valuable insights.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MCCALLION, ANDREW S — JOHNS HOPKINS UNIVERSITY
- Study coordinator: MCCALLION, ANDREW S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.