NIH-funded research NIH-funded research

Understanding what causes ovarian cancer to come back after treatment

Official title: Identifying factors associated with ovarian cancer recurrence using a population-based approach

Funded at Emory University · NIH-11211522 · Data updated 2026-11-12

This study is looking at what causes ovarian cancer to come back after treatment, focusing on the genes and other markers that might help predict this, so that women with ovarian cancer can get better, more personalized care in the future.

More Ovarian Cancer research and trials

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionEmory University
NIH-funded
Lab location1 site (Atlanta, United States)
Project startFebruary 1, 2023
Project endDecember 31, 2027
Funding year2025
Award (this year)$248,858
NIH project number4R00CA277580-03
Project IDNIH-11211522 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research are individuals who have been diagnosed with ovarian cancer and are in remission after initial treatment.

Less likely to help

Patients who have not been diagnosed with ovarian cancer or those who are currently undergoing treatment may not benefit from this research.

What this research studies

This research investigates the factors that contribute to the recurrence of ovarian cancer after initial treatment. By analyzing gene expression signatures and other biological markers, the study aims to identify distinct characteristics of ovarian cancer that may predict the likelihood of recurrence. Patients who have been diagnosed with ovarian cancer will be the focus, as the research seeks to gather data from a diverse population to enhance the understanding of this disease. The findings could lead to improved prognostic tools and personalized treatment strategies for patients.

Why it matters

Potential benefit: If successful, this research could lead to better predictions of ovarian cancer recurrence, allowing for more tailored and effective treatment plans.

How similar studies have gone: Previous research has shown promise in using gene expression signatures to predict cancer outcomes, suggesting that this approach could yield valuable insights.

Where this research is happening

  • Emory University
    Atlanta, United States
    Active

Researchers

  • Principal investigator: Collin, Lindsay Jane — Emory University
  • Study coordinator: Collin, Lindsay Jane

Related research

Other NIH-funded projects on the same topics.

  • Why prostate cancer spreads more often in African-American men

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    NIH research Emory University · Atlanta, United States · NIH-11260239

  • Vaccine to help prevent ovarian cancer from coming back

    This vaccine trains Th17 immune cells to help women in first remission from high-grade ovarian cancer stay cancer-free after surgery and chemotherapy.

    NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11178557

  • Targeting Hedgehog signaling to improve treatment for ovarian cancer

    This study is looking at how a specific pathway in ovarian cancer cells can be targeted to help make treatments work better for patients whose cancer keeps coming back after initial therapies.

    NIH research Texas Tech University Health Scis Center · Lubbock, United States · NIH-10545765

  • Improving early detection of ovarian cancer recurrence using MUC16 analysis

    This study is working on a new way to detect if high-grade serous ovarian cancer comes back by looking at a specific protein in the blood, which could help doctors catch it earlier and manage treatment better for women facing this condition.

    NIH research University of Kansas Lawrence · Lawrence, United States · NIH-10543477

  • Keloid recurrence study using multi-omics in diverse patients

    A research effort will look at why keloids come back after surgery, especially in African American patients, using comprehensive molecular data from patient samples.

    NIH research Henry Ford Health + Michigan State University Health Sciences · East Lansing, United States · NIH-11641647

  • Understanding the experience of ovarian cancer after diagnosis to improve survivorship

    This NIH grant funds a mixed-methods study to better understand physical and emotional challenges faced by ovarian cancer survivors and how supportive care can help them live better after diagnosis.

    NIH research University of Minnesota · Minneapolis, United States · NIH-11624191

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.