Understanding what causes cancer to spread to the liver
Determinants of Liver Metastasis
This study is looking into why some cancers, like colon, pancreas, and prostate cancer, spread to the liver more than others, so we can better understand how to help patients facing this serious issue.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10783690 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind liver metastasis, which is when cancer spreads to the liver, a common and serious issue for many cancer types. The program aims to identify both shared and unique factors that contribute to liver metastasis in cancers such as colon, pancreas, and prostate. By studying the liver's microenvironment and how it interacts with cancer cells, the research seeks to uncover why some tumors are more likely to spread to the liver than others. The approach combines molecular biology with clinical expertise to explore how changes in liver tissue can affect cancer progression.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with colon, pancreatic, or prostate cancer who are at risk of liver metastasis.
Not a fit: Patients with cancers that do not typically metastasize to the liver may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating liver metastasis in cancer patients.
How similar studies have performed: Previous research has shown promising results in understanding cancer metastasis, but this program aims to explore novel mechanisms specific to liver metastasis.
Where this research is happening
Los Angeles, United States
- Cedars-Sinai Medical Center — Los Angeles, United States (Active)
Researchers
- Principal investigator: Lu, Shelly Chi-Loo — Cedars-Sinai Medical Center
- Study coordinator: Lu, Shelly Chi-Loo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.