Understanding visual sensitivity in Neurofibromatosis type 1
Midbrain pathways for visual hypersensitivity in neurofibromatosis type 1
['FUNDING_R01'] · CINCINNATI CHILDRENS HOSP MED CTR · NIH-11093999
This project explores how the brain processes visual information differently in people with Neurofibromatosis type 1, especially those with attention issues.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CINCINNATI CHILDRENS HOSP MED CTR (nih funded) |
| Locations | 1 site (CINCINNATI, UNITED STATES) |
| Trial ID | NIH-11093999 on ClinicalTrials.gov |
What this research studies
Many people with Neurofibromatosis type 1 (NF1) experience challenges like attention deficits and hyperactivity. We've noticed that mice with NF1 show increased sensitivity to visual stimuli, like sudden movements. This project aims to understand how a specific part of the brain, called the superior colliculus, and the nerve cells that send visual signals to it, contribute to this visual sensitivity in NF1. By studying these brain mechanisms, we hope to uncover why visual information is processed differently.
Who could benefit from this research
Good fit: This foundational research is most relevant to patients with Neurofibromatosis type 1, particularly those experiencing attention deficits, hyperactivity, or other cognitive symptoms.
Not a fit: Patients without Neurofibromatosis type 1 or related cognitive symptoms may not directly benefit from this specific foundational research.
Why it matters
Potential benefit: This work could help us better understand the brain changes in NF1 that lead to attention problems and other cognitive symptoms, potentially leading to new ways to help manage these challenges.
How similar studies have performed: Previous work has shown that mice with NF1 have visual hypersensitivity, and nerve cells in NF1 are more excitable, providing a foundation for this current investigation.
Where this research is happening
CINCINNATI, UNITED STATES
- CINCINNATI CHILDRENS HOSP MED CTR — CINCINNATI, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ROBINSON, JOHN ELLIOTT — CINCINNATI CHILDRENS HOSP MED CTR
- Study coordinator: ROBINSON, JOHN ELLIOTT
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Attention deficit hyperactivity disorder