Understanding vision problems caused by cone opsin mutations and finding treatments
Disease mechanisms of cone opsin mutants and treatment strategies
This study is looking at how changes in certain genes that help us see colors might affect vision, and it's for people who have color vision problems or cone dystrophy, with the hope of finding new treatments that could help improve their sight.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | West Virginia University NIH-funded |
| Lab location | 1 site (Morgantown, United States) |
| Project ID | NIH-10673588 on NIH RePORTER |
What this research studies
This research investigates the genetic mutations in cone opsins, which are crucial for color and central vision. By studying these mutations in living models, the researchers aim to uncover how they affect vision and explore potential treatment strategies, including gene therapy. The approach involves analyzing the structure and function of cone opsins to understand their role in visual disorders. Patients may benefit from insights that could lead to new therapies for conditions like color vision deficiency and cone dystrophy.
Who could benefit from this research
Good fit: Ideal candidates include individuals with genetic mutations affecting their color vision or those diagnosed with related visual disorders.
Not a fit: Patients without genetic mutations affecting cone opsins or those with unrelated vision problems may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for patients with vision disorders caused by cone opsin mutations.
How similar studies have performed: Previous research has shown promise in using gene therapy for similar genetic vision disorders, indicating potential for success in this area.
Where this research is happening
Morgantown, United States
- West Virginia University — Morgantown, United States (Active)
Researchers
- Principal investigator: Deng, Wen-Tao — West Virginia University
- Study coordinator: Deng, Wen-Tao
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.