Understanding Venous Malformations to Find New Treatments
Venous Malformations (VM): A Murine Mdoel to Identify Therapies to Target Aberrant Venous Development
This research explores the causes of venous malformations in a mouse model to discover new ways to treat this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-11013343 on NIH RePORTER |
What this research studies
Venous malformations are abnormal veins that are present at birth and continue to grow, causing pain and serious health problems. Current treatments like sclerotherapy and surgery only manage symptoms and often require repeated procedures. This project uses a mouse model to understand the underlying genetic and cellular changes that lead to these malformations. By uncovering how these abnormal veins develop, we hope to find new, targeted treatments that address the root cause of the condition.
Who could benefit from this research
Good fit: This foundational research focuses on understanding venous malformations, a condition that often affects children aged 0-11 years.
Not a fit: Patients will not directly participate in this laboratory-based research, so there is no immediate direct benefit for individuals.
Why it matters
Potential benefit: If successful, this work could lead to the development of new, more effective treatments for venous malformations that target the disease's origin rather than just its symptoms.
How similar studies have performed: Previous work by this team has already shown that targeting a specific protein, c-ABL, significantly reduced the size of abnormal blood vessels, suggesting a promising direction.
Where this research is happening
Cincinnati, United States
- Cincinnati Childrens Hosp Med Ctr — Cincinnati, United States (Active)
Researchers
- Principal investigator: Boscolo, Elisa — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Boscolo, Elisa
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.