Understanding VAV1 Changes in T-cell Lymphomas
Role and Mechanisms of VAV1 alterations in Peripheral T-cell Lymphomas
This work explores how specific genetic changes in a gene called VAV1 contribute to a type of blood cancer called Peripheral T-cell Lymphoma, aiming to find new ways to treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11097155 on NIH RePORTER |
What this research studies
Peripheral T-cell lymphomas (PTCLs) are a group of blood cancers that are not well understood and often have a poor outlook. We recently found new genetic changes in a gene called VAV1 in PTCLs, which appear to drive the growth of these cancers. This project aims to uncover exactly how these VAV1 changes cause lymphoma to develop and to discover new treatment options in laboratory models. By understanding these mechanisms, we hope to identify specific weaknesses in the cancer that can be targeted with new medicines.
Who could benefit from this research
Good fit: This foundational research focuses on understanding the biology of Peripheral T-cell Lymphomas, and while it does not directly involve patient participation, future clinical trials stemming from this work would target patients diagnosed with PTCLs, particularly those with VAV1 alterations.
Not a fit: Patients without Peripheral T-cell Lymphoma or those whose lymphoma does not involve VAV1 alterations may not directly benefit from this specific line of research.
Why it matters
Potential benefit: If successful, this work could lead to a better understanding of Peripheral T-cell Lymphomas and the development of new, more effective therapies for patients.
How similar studies have performed: While the specific VAV1 alterations are newly identified, similar approaches of understanding genetic drivers in cancer have successfully led to targeted therapies in other lymphoma types.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Palomero, Teresa — Columbia University Health Sciences
- Study coordinator: Palomero, Teresa
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.