Understanding urinary infections in children with spina bifida
The association between the urine microbiome, the host immune response and urinary symptoms in children with spina bifida
This study is looking at how the germs in urine and the body's immune system affect urinary problems in kids with spina bifida, with the hope of creating a better way to test for urinary tract infections in these children.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10773161 on NIH RePORTER |
What this research studies
This research investigates how the urine microbiome and the body's immune response relate to urinary symptoms in children with spina bifida. The study aims to develop a diagnostic method for urinary tract infections (UTIs) in this population, which currently lacks accurate testing methods. Researchers will analyze clinical data and use mouse models to explore the relationship between urine microbial diversity and urinary biomarkers. The ultimate goal is to create an algorithm that helps identify children who need UTI testing.
Who could benefit from this research
Good fit: Ideal candidates for this research are children with spina bifida who experience urinary symptoms.
Not a fit: Patients without spina bifida or those who do not exhibit urinary symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and management of urinary tract infections in children with spina bifida.
How similar studies have performed: Other research has shown promise in understanding the role of the microbiome in urinary health, but this specific approach is novel.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Forster, Catherine S — University of Pittsburgh at Pittsburgh
- Study coordinator: Forster, Catherine S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.