Understanding Unique Peptides in Pancreatic Cells for Type 1 Diabetes
Characterize the Landscape and Origin of Hybrid Peptides in Beta Cells
['FUNDING_R01'] · UNIVERSITY OF COLORADO DENVER · NIH-11134660
This project explores how special protein fragments in the pancreas might trigger the immune system to cause Type 1 Diabetes.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF COLORADO DENVER (nih funded) |
| Locations | 1 site (Aurora, UNITED STATES) |
| Trial ID | NIH-11134660 on ClinicalTrials.gov |
What this research studies
Our bodies' immune systems sometimes mistakenly attack insulin-producing cells in the pancreas, leading to Type 1 Diabetes. This project focuses on unusual protein pieces, called hybrid insulin peptides (HIPs), that form in these pancreatic cells. We believe these HIPs might be what the immune system targets, causing the disease. Researchers are studying how these HIPs are created and how a cellular process called autophagy affects their presence, aiming to uncover why the immune system turns against the body's own cells.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients, but future studies building on this work might seek individuals with Type 1 Diabetes or those at risk.
Not a fit: Patients currently seeking immediate new treatments for Type 1 Diabetes would not directly benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to new ways to prevent or treat Type 1 Diabetes by understanding and potentially targeting these specific immune responses.
How similar studies have performed: Previous findings have identified these hybrid peptides in animal models and human samples, suggesting they play a role in Type 1 Diabetes.
Where this research is happening
Aurora, UNITED STATES
- UNIVERSITY OF COLORADO DENVER — Aurora, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DELONG, THOMAS — UNIVERSITY OF COLORADO DENVER
- Study coordinator: DELONG, THOMAS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.