Understanding UBR5 in Lymphoma
Dissecting the Role Ubiquitin E3 Ligase UBR5 in Lymphomagenesis
This project aims to understand how a specific protein called UBR5 contributes to the development of mantle cell lymphoma, a type of blood cancer.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Utah State Higher Education System--University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-11141782 on NIH RePORTER |
What this research studies
Mantle cell lymphoma (MCL) is a serious and uncommon type of non-Hodgkin's lymphoma with limited treatment options. We know that many MCL patients have a specific genetic change, but additional mutations are needed for the disease to fully develop. Recent discoveries show that a protein called UBR5 is often mutated in MCL patients, especially in a key part of the protein. This protein helps control how other proteins are broken down in the body. By studying how UBR5 works in models, we hope to uncover new ways the disease progresses.
Who could benefit from this research
Good fit: This foundational research is for patients interested in the underlying causes of mantle cell lymphoma and the development of future therapies.
Not a fit: Patients seeking immediate new treatments or direct clinical intervention would not directly benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could reveal new molecular targets for developing more effective treatments for mantle cell lymphoma.
How similar studies have performed: This project builds on recent genetic sequencing discoveries in MCL patients, exploring a novel mutation that has not been extensively studied in this context.
Where this research is happening
Salt Lake City, United States
- Utah State Higher Education System--University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Buckley, Shannon — Utah State Higher Education System--University of Utah
- Study coordinator: Buckley, Shannon
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.