Understanding Type 2 Inflammation in Allergic Disease and Parasite Infections
Role of the prostaglandin D2 receptor CRTH2 in helminth-induced type 2 inflammation in the intestine
This research explores how a specific molecule called CRTH2 affects the body's immune response in allergic diseases and infections caused by parasites.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11161455 on NIH RePORTER |
What this research studies
Many people worldwide suffer from allergic diseases and parasite infections, both of which involve a strong immune reaction called Type 2 inflammation. This project uses a model to understand how hookworm-like parasites trigger this inflammation in different body parts, like the lungs and gut. We are looking closely at how two specific molecules, PGD2 and its partner CRTH2, guide the immune system's response. By understanding these molecules, we hope to uncover new ways the body fights off these conditions.
Who could benefit from this research
Good fit: This foundational research is relevant to anyone affected by allergic conditions or parasitic infections, as it seeks to understand the underlying immune responses.
Not a fit: Patients will not directly participate in this laboratory-based research, so there is no immediate personal benefit.
Why it matters
Potential benefit: If successful, this work could lead to new ways to treat allergic diseases and parasitic infections by targeting specific immune pathways.
How similar studies have performed: While the general mechanisms of Type 2 inflammation are known, this project uses novel tools to explore the specific roles of PGD2 and CRTH2, offering a new perspective.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Tait Wojno, Elia D — University of Washington
- Study coordinator: Tait Wojno, Elia D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.