Understanding tumor differences in triple negative breast cancer to predict patient outcomes
Quantitative characterization of tumor heterogeneity using habitat imaging for the prediction of patient outcome in triple negative breast cancer
This study is looking at how different areas within tumors in patients with triple negative breast cancer can affect their response to new treatments, and it aims to use special imaging techniques to help doctors predict which patients might benefit the most from these therapies, making treatment more effective and less stressful.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10947543 on NIH RePORTER |
What this research studies
This research focuses on using advanced imaging techniques to analyze the diverse environments within tumors in patients with triple negative breast cancer (TNBC). By employing a method called habitat imaging, the study aims to identify distinct tumor subregions that may influence how well patients respond to treatments, particularly new immunotherapies. The goal is to develop a noninvasive way to predict which patients are more likely to benefit from specific therapies, potentially improving treatment outcomes and reducing unnecessary side effects. Patients will undergo multiparametric magnetic resonance imaging (mpMRI) to gather detailed information about their tumors before treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with triple negative breast cancer who are preparing to start treatment.
Not a fit: Patients with non-triple negative breast cancer or those who are not eligible for immunotherapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more personalized treatment plans for patients with triple negative breast cancer, improving their chances of successful outcomes.
How similar studies have performed: Other research has shown promise in using imaging techniques to characterize tumor environments, suggesting that this approach could be effective in predicting treatment responses.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Kazerouni, Anum Syed — University of Washington
- Study coordinator: Kazerouni, Anum Syed
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.